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Receptor binding domain (RBD) sequence alignment of the spike subunit S1 within different groups of human coronaviruses. Amino acid sequences of SARS-CoV-2 and SARS-CoV-1 (group 2b), HCoV-HKU-1 and HCoV-OC43 (group 2a), HCoV-NL63, and HCoV-229E (group 1b), and MERS-CoV are shown. Conserved amino acids within each group are denoted as dots and highlighted in cyan.
