Table 3.
Extent of genetic conservation in 3CL-Protease, RNA-dependent RNA polymerase and in the spike protein in the different human coronaviruses.
| Coronavirus species | % of conserved residues (N of conserved residues/Total N of residues in a protein)a |
|||
|---|---|---|---|---|
| 3CL-PR | RdRp | Spike subunit 1 |
Spike subunit 2 |
|
| Group 2b | ||||
| SARS-CoV-2 | 98.0 (300/306) | 98.8 (560/567) | 98.4 (674/685) | 98.6 (580/588) |
| SARS-CoV-1 | 98.7 (302/306) | 97.5 (553/567) | 98.1 (654/667) | 99.1 (583/588) |
| Group 2c | ||||
| MERS-CoV | 95.4 (292/303) | 99.8 (566/567) | 96.9 (728/751) | 98.0 (590/602) |
| Group 2a | ||||
| HCoV-OC43 | 93.4 (283/303) | 99.6 (565/567) | 85.9 (663/772) | 96.0 (571/595) |
| HCoV-HKU1 | 98.7 (299/303) | 99.5 (564/567) | 97.4 (740/760) | 99.7 (594/596) |
| Group 1b | ||||
| HCoV-NL63 | 99.0 (300/303) | 95.9 (544/567) | 87.8 (657/748) | 96.4 (586/608) |
| HCoV-229E | 97.4 (294/302) | 98.1 (556/567) | 91.2 (515/565) | 98.2 (595/606) |
For SARS-CoV-2, conserved residues are defined as those in which aa substitutions are observed with a frequency <0.1 %, while for all other coronaviruses, conserved residues were defined as those in which no aa substitutions were observed.
Abbreviations: 3CL-PR, 3CL protease; RdRp, RNA-dependent RNA polymerase.
Number of sequences analyzed are: 11,918 for SARS-CoV-2 3CL-PR, 11,185 for SARS-CoV-2 RdRp, and 9,111 for SARS-CoV-2 Spike, 40 for SARS-CoV-1 3CL-PR, RdRP and Spike, 126 for HCoV-OC43 3CL-PR, RdRP and Spike, 55 for HCoV-NL63 3CL-PR, RdRP and Spike, 20 for HCoV-229E 3CL-PR, RdRP and Spike, 15 for HCoV-HKU1 3CL-PR, RdRP and Spike, and 242 for MERS-CoV 3CL-PR, RdRP and Spike.