Table 4.
Degree of amino acid identity in 3CL-Protease, RNA-dependent RNA polymerase and in the spike protein across the different human coronaviruses compared to SARS-CoV-2.
| Coronavirus species | % of similarity (N of identical amino acid residue compared to SARS-CoV-2)a |
|||
|---|---|---|---|---|
| 3CL-PR | RdRp | Spike subunit 1 |
Spike subunit 2 |
|
| Group 2b | ||||
| SARS-CoV-1 | 96.1 (294) | 98.2 (557) | 63.9 (438) | 90.0 (529) |
| Group 2a | ||||
| HCoV-OC43 | 48.4 (148) | 71.6 (406) | 21.3 (146) | 41.0 (241) |
| HCoV-HKU1 | 49.0 (150) | 71.8 (407) | 20.6 (141) | 38.6 (227) |
| Group 1b | ||||
| HCoV- NL63 | 43.5 (133) | 60.1 (341) | 17.7 (121) | 32.8 (193) |
| HCoV-229E | 40.8 (125) | 61.7 (344) | 15.3 (105) | 33.8 (199) |
| Group 2c | ||||
| MERS-CoV | 50.3 (154) | 75.3 (427) | 19.3 (132) | 43.0 (253) |
The degree of identity is calculated as the % of identical amino acid residues in a specific protein between SARS-CoV-2 and each of the other human coronaviruses. The denominator used to calculate the % is the number of residues in SARS-CoV-2 proteins: 306 for 3CL-PR, 567 for RdRp, 685 for the spike subunit 1 and 588 for the spike subunit 2.
Abbreviations: 3CL-PR, 3CL protease; RdRp, RNA-dependent RNA polymerase.
Number of sequences analyzed are: 11,918 for SARS-CoV-2 3CL-PR, 11,185 for SARS-CoV-2 RdRp, and 9,111 for SARS-CoV-2 Spike), 40 for SARS-CoV-1 3CL-PR, RdRP and Spike, 126 for HCoV-OC43 3CL-PR, RdRP and Spike, 55 for HCoV-NL63 3CL-PR, RdRP and Spike, 20 for HCoV-229E 3CL-PR, RdRP and Spike, 15 for HCoV-HKU1 3CL-PR, RdRP and Spike, and 242 for MERS-CoV 3CL-PR, RdRP and Spike.