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. 2020 Jun 2;9(1):1149–1159. doi: 10.1080/22221751.2020.1770630

Figure 4.

Figure 4.

Synergistic effect of β-lactam antibiotics and membrane damage agents on the killing of A. baumannii. (A) The effect of 1% Trition X-100 on the survival of bacterial persisters from the treatment of meropenem (6 μg/mL) or kanamycin (40 μg/mL) or ofloxacin (40 μg/mL). (B–D) The combination of β-lactam antibiotics and colistin enhances the killing on A. baumannii. Bacteria were treated by the combination of 0.5 μg/mL of meropenem and 2 μg/mL of colistin for 1h (B) or for a time-course treatment by 30 μg/mL of carbenicillin and 2 μg/mL of colistin (C) or 200 μg/mL of ampicillin and 2 μg/mL of colistin (D). The values represent the mean ± SD from of three independent experiments (*: p value <0.05 ***: p value <0.001).