Table 1. Inhibition spectrum of RA against different viruses.
| Cell line or virus strain | CC50 (μM)a | EC50 (μM)b | SIc |
|---|---|---|---|
| RD cellsd | 327.68 ± 14.43 | ||
| A549 cells | 216.82 ± 14.61 | ||
| EV-71/Taiwan/50995/12 (genotype B) | 31.57 ± 4.14 | 10.36 | |
| EV-71/Taiwan/51045/12 (genotype B) | 35.15 ± 1.21 | 9.30 | |
| EV-71/Taiwan/51126/12 (genotype B) | 39.13 ± 2.51 | 8.36 | |
| EV-71/Taiwan/2557/12 (genotype B) | 36.58 ± 1.42 | 8.94 | |
| EV-71/Taiwan/2231/98 (genotype C) | 41.41 ± 0.45 | 7.90 | |
| EV-71/Taiwan/4643/98 (genotype C) | 82.43 ± 0.79 | 3.97 | |
| EV-71/Taiwan/4643/MP4 (genotype C) | 114 ± 4.10 | 2.87 | |
| Adenovirus | >100 | ||
| EV-D68 Taiwan/14-02795 | >100 | ||
| EV-D68 US/KY/14-18953 | >100 | ||
| EV-D68 US/MO/14-18947 | >100 |
aCC50: Drug concentration that caused 50% cytotoxicity. bEC50: Concentration of compounds that inhibited cytopathic effects caused by 50% of the viruses. EC50 values are the mean ± SD of the results from two to three independent experiments. cSI: CC50/EC50. dRD cells were used for enteroviruses and A549 were used for adenovirus.