Table 3.
Exploration of possible prognostic or prescriptive effects of autonomic and endocrine parameters on posttraumatic stress disorder (PTSD) symptoms 1.5 (intercept), 3 and 6 months posttrauma (linear slope).
| Effect on the intercept |
Effect on the linear slope |
|||||||
|---|---|---|---|---|---|---|---|---|
| b (SEM) | t | p | 95% CI | b (SEM) | t | p | 95% CI | |
| Effect of DST AUCg in women using hormonal contraception (n = 11) | ||||||||
| Reference | 4.34 (.65) | 6.70 | <.01 | 3.07; 5.61 | −.44 (.09) | −4.75 | <.01 | −.62; −.26 |
| Age | −.11 (.36) | −.31 | .76 | −.82; .60 | ||||
| Days between trauma and T2 | .63 (.81) | .78 | .44 | −.96; 2.23 | ||||
| Pre-treatment PTSD symptoms | .78 (.33) | 2.36 | .02 | .13; 1.43 | ||||
| Treatment | 1.92 (.90) | 2.13 | .03 | .16; 3.68 | −.35 (.18) | −1.90 | .06 | −.71; .01 |
| DST AUCg | −1.17 (.28) | −4.11 | <.01 | −1.73; −.61 | .19 (.09) | 2.16 | .03 | .02; .37 |
| Effect of DST AUCi in men (n = 15) | ||||||||
| Reference | 4.15 (.33) | 11.68 | <.01 | 3.45; 4.84 | −.16 (.08) | −2.03 | .04 | −.32; −.00 |
| Age | −.04 (.33) | −.12 | .90 | −.68; .60 | ||||
| Days between trauma and T2 | .13 (.40) | .32 | .75 | −.66; .92 | ||||
| Pre-treatment PTSD symptoms | .49 (.33) | 1.46 | .14 | −.17; 1.14 | ||||
| Treatment | 1.04 (.70) | 1.49 | .14 | −.33; 2.41 | ||||
| DST AUCi | .75 (.34) | 2.17 | .03 | .07; 1.42 | ||||
| Effect of resting oxytocin in women using hormonal contraception (n = 17) | ||||||||
| Reference | 4.63 (.35) | 13.28 | <.01 | 3.95; 5.32 | −.43 (.10) | −4.16 | <.01 | −.63; −.23 |
| Age | .37 (.30) | 1.24 | .22 | −.21; .95 | ||||
| Days between trauma and T2 | −.10 (.30) | −.32 | .75 | −.68; .49 | ||||
| Pre-treatment PTSD symptoms | .34 (.35) | .96 | .34 | .36; 1.03 | ||||
| Treatment | −.26 (.79) | −.34 | .74 | −1.80; 1.28 | −.17 (.21) | −.83 | .40 | −.58; .23 |
| Resting oxytocin | .87 (.33) | 2.67 | .01 | .23; 1.51 | ||||
The table summarizes the final models with significant prognostic or prescriptive effects of autonomic or endocrine parameters. Effects of morning cortisol suppression by dexamethasone (DST, area under the curve with respect to the ground, AUCg), cortisol awakening response suppression by DST (area under the curve with respect to increase AUCi) and resting endogenous oxytocin concentrations on post-traumatic stress disorder (PTSD) symptoms over follow-up time points in men and women using hormonal contraception are presented. Age, days between trauma and T2, pre-treatment PTSD symptoms and the endocrine parameters are metric and were z-transformed. Treatment condition, a dichotomous variable, was unweighted contrast coded (−.5 = placebo condition and .5 = oxytocin condition). Reference indicates the effect of all parameters set at their mean. Bold values indicate significant p values.