Figure 4.
Histological findings from neutropenic mice intravenously challenged with Candida auris. Normal (A) and damaged heart (B) with Mallory’s PTAH staining. PTAH staining performed on the heart of a moribund dissected mouse on day 5 infected with isolate 196 (B) revealed contraction band necrosis or myofibrillar degeneration (yellow arrows). Morphology of C. auris with Periodic Acid Schiff (PAS) staining in the heart’s arterioles on day 1 post infection (C), and in the spleen (D). PAS staining showed blastoconidia and budding yeast cells but never pseudohyphae and hyphae (C–D). Magnification, A-B × 400, C × 1000, D × 400, RBC; red blood cells.