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Dermorphin glycopeptides containing both O- and C-linked carbohydrate moieties were evaluated in vitro and in vivo. Stability studies showed that the glycopeptide analogues were more stable compared to the un-glycosylated control compounds. Penetration studies revealed that the C-linked galactosylated glycopeptide exhibited the most efficient BBB penetration. (Rocchi 1999) [93, 94].
