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Morphiceptin glycopeptides containing either glucosylated or galactosylated hydroxyproline moieties were less potent than morphine in vivo. Interestingly, this is the opposite result of incorporating a carbohydrate moiety into opioid peptides. This indicates that morphiceptin adopts a different bioactive conformation than opioid peptides do. (Valencia 1990) [123].
