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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Peptides. 2020 Jul 13;131:170369. doi: 10.1016/j.peptides.2020.170369

Figure 7. Opioid Glycopeptide Derived from DPDPE.

Figure 7.

Glycopeptides related to the [Met5] enkephalinamide and DPDPE were synthesized and studied for antinociception in vivo. One particular glucosylated analogue of DPDPE produced analgesia following i.p. administration. Naloxone administration antagonized the effects of this glycopeptide following i.c.v. administration but not i.p. administration, suggesting this glycopeptide is able to penetrate the BBB and act in the CNS. (Polt 1994) [77].