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. 2020 Aug 26;21:216. doi: 10.1186/s13059-020-02140-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effects of MARCO^high TAMs in vivo and ex vivo. a Representative hematoxylin and eosin staining of mouse brains orthotopically co-implanted with GSCs and either control, monocytes, MARCO^low TAMs, or MARCO^high TAMs. Each group was injected with 5 mice. b Kaplan-Meier survival curve analysis of the mouse models. c Representative immunohistochemical images of mesenchymal markers including CD44, YKL40, TOP2A, SERPINE1, and BCL2A1 in mouse models. d qRT-PCR analysis of stemness and invasive markers from ex vivo tumor specimens isolated from mouse models. e The 1/stem cell frequency of GSCs isolated from model mice and subjected to 2 or 5 Gy ionizing radiation. *P ≤ 0.05, **P ≤ 0.01, ***, P ≤ 0.001. Data shown in c and e are representative of two independent and reproducible experiments. Data shown in d are representative of three independent and reproducible experiments