Table 2.
Baseline characteristics of enrolled participants for each trial included in meta-analysis: I
| Author (year) | Primary outcome | Chest X-ray cavities present, number (I/C) b |
aChest X-ray Zones affected (mean, SD)(I/C) |
BMI (mean, SD)(kg/m2)(I/C) | TB score (mean, SD)(I/C) | CRP (mean, SD) (mg/L)(I/C) | ESR (mean, SD) (mm/h)(I/C) |
|---|---|---|---|---|---|---|---|
| Martineau 2011 [21] | sputum culture conversion | 36 (58)/36 (56) | 2.8 (1.3)/ 2.8 (1.3) | 20.1 (3.1)/20.2 (2.7) | ND | 71.4 (49.5)/60.5 (45.0) | 62.1 (23.1) /60.9 (17.4) |
| Daley 2015 [16] | sputum culture conversion | ND | ND | 18.0 (2.9)/17.8 (3.0) | ND | ND | ND |
| Farazi 2017 [36] | TB clinical score sputum conversion (co-primary) | ND | ND | 20.75 (3.8) /21.2 (4.1) | 6.3 (2.4)/ 6.1 (2.2) | 26 (86.7%) /25 (83.3%) | 25 (83.3%)/27 (90%) |
| Mily 2015 [18] | sputum culture conversion, TB clinical score (co-primary) | ND | ND | NM | 7.9 (5.6)/ 8.0 (5.0) | 26.2 (0.4)/32.1 (0.4) | 55.9 (48.4)/60.2 (34.9) |
| Nursyam 2006 [37] | sputum conversion | ND | ND | 16.87 (2.06)/ 17.68 (2.54) | ND | ND | ND |
| Ralph 2013 [20] | sputum culture conversion, TB clinical score (co-primary) | 42 (25–73)/ 36.5 (20.5–57.5) | 70 (36–94)/ 66.5 (29.5–91) | 19.1 (13.3–32.5)/ 19.3 (12.0–26.3) | 6.9 (2.0)/ 6.8 (1.9) | ND | ND |
| Salahuddin 2013 [14] | Weight gain, chest radiograph resolution (Co-primary). | 3.61 (1.40)/3.64 (1.48) | ND | 17.2 (11–25)/17.3 (11–27) | 6.68 (2.04)/ 6.85 (2.50) | ND | ND |
| Tukvadze 2015 [39] | sputum culture conversion | 15 (15.0)/21 (21.2) | ND | ND | ND | ND | ND |
| Wejse 2009 [38] | TB clinical score | ND | ND | 18.8 (12–33)/18.5 (12–27) | 6.7 (6.4–7.0)/ 6.8 (6.5–7.1) | ND | ND |
| Johnson 2003 [40] | sputum culture conversion | 54 (98)/52 (95) | ND | NM | ND | ND | ND |
| Mayanja-Kizza 2005 [41] | Treatment safety | ND | ND | 19 (2.8)/19 (2.6) | ND | ND | ND |
| Pedral-Sampaio 2003 [44] | Treatment tolerance | ND | ND | ND | ND | ND | ND |
| Willis 1996 [42] | Effect on treatment | ND | ND | ND | ND | ND | ND |
| Mahakalkar 2017 [43] | sputum conversion | 11.01 ± 2/9.27 ± 1.93c | ND | ND | ND | ND | ND |
| Ganmaa 2017 [15] | Sputum culture conversion | 95 (50.0)/100 (50.0) | 7.4 (4.4)/7.3 (4.4) | 19.7 (2.8)/20.1 (3.1) | ND | 62.7 (46.1)/ 63.0 (46.7) | 17.2 (10.7)/15.8 (11.3) |
ND not determined, I/C intervention & control groups, SD standard deviation, mm/h millimetres/hour, mg/L milligram/litre, kg/m kilogram/metre, BMI body mass index, TB tuberculosis, CRP C-reactive protein, ESR erythrocyte sedimentation rate
a:Chest radiograph; b:in percentage(%); c: mean value