Table 2.
Sepsis and mortality before and after guideline update
| Year of discharge | 2011–2013 n = 3.920 (%, 95 CI) |
2014–2018 n = 8.903 (%, 95 CI) |
p# |
|---|---|---|---|
| Sepsis with positive blood culture | 16.5 (15.3–17.6) | 14.4 (13.7–15.1) | 0.003 |
| Clinical sepsisa | 42.8 (41.1–44.6) | 31.4 (30.4–32.4) | < 0.001 |
| Early-onset sepsisa with positive blood culture | 1.7 (1.3–2.2) | 1.4 (1.2–1.8) | 0.3 |
| Late-onset sepsisa with positive blood culture | 17.0 (15.7–18.4) | 14.9 (14.0–15.8) % | 0.008 |
| Gram positive sepsis | 13.2 (12.2–14.3) | 11.2 (10.6–11.9) % | 0.001 |
| Gram negative sepsis | 3.8 (3.2–4.4) | 3.4 (3.0–3.8) % | 0.26 |
| KRINKO I/MDRO sepsis | 0.5 (0.3–0.7) | 0.6 (0.5–0.8) % | 0.36 |
| KRINKO II sepsis | 2.0 (1.6–2.5) | 2.2 (1.9–2.6) % | 0.49 |
| KRINKO III sepsis | 1.1 (0.8–1.5) | 1.1 (0.9–1.3) % | 0.98 |
| Candida sepsis | 0.5 (0.3–0.7) | 0.4 (0.3–0.6) % | 0.52 |
| Sepsis related mortality | 2.3 (1.8–2.8) | 2.1 (1.8–2.4) % | 0.54 |
|
Total mortality (%, 95 CI) |
13.8 (12.8–14.9) | 12.5 (11.8–13.2) % | 0.036 |
KRINKO I – all MDRO, KRINKO II – Acinetobacter spp., Klebsiella spp., S. aureus without MDRO; KRINKO III – pathogens with high epidemic potential but no MDRO i.e. Serratia marcescens, Pseudomonas aeruginosa, Klebsiella and Enterobacter spp. #Fisher’s exact test (two-sided)
aThe data is based on the population of infants enrolled in the GNN (n = 2.948/6.630)