Table 1.
Nano-drug delivery systems available in the clinical practice for systemic microbial infections treatment.
| Clinical product | System | Year of clinical approval | Drug | Administration | System composition | Proportion | Dose | Objective/indication |
|---|---|---|---|---|---|---|---|---|
| Abelcet® | L | 1996 | Amphotericin B | I.V | Dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol | 7/3 M | 5 mg/Kg/day | Invasive severe fungal infections |
| Ambisome® | L | 1997 | Amphotericin B | I.V | Hydrogenated soy phosphatidylcholine, cholesterol, distearoylphosphatidylglycerol and AmB | 2/1/0.8/0.4 M | 3 mg/Kg/day | Fungal infections |
| Amphotec® | L | 1996 | Amphotericin B | I.V | Cholesteryl sulphate:Amphotericin B | 1/1 M | 1 at 5 3 mg/Kg/day | Several fungal infections |
| Epaxal® | L | 1993 | Inactivated hepatitis A virus | I.M | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine and dioleoylphosphatidylcholine | 25/75 M | 0.25 mL | Hepatitis A |
| Inflexal® V | L | 1997 | Inactivated hemaglutinine of Influenza virus strains A and B | I.M | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine and dioleoylphosphatidylcholine | 25/75 M | Single full of 0.5 mL or two dose pf 0.25 mL | Influenza A and B |
| NB-001 | N | – | Oil-in-water emulsion | TP | Soybean oil, water, ethanol, edetate disodium dihydrate Tween® 20 cetylpyridinium chloride | – | NB-001 (0.3%) | Recurrent Herpes Labialis |
N: Nanoemulsion.; L: Liposome.; I.V: Intravenous.; I.M: Intramuscular.; TP: Topical.; M: Molar.