Table 6.
Nanoemulsions applied to the treatment of systemic infections.
| Formulation | Drug | Composition | Therapeutic target | Route of administration | Reference |
|---|---|---|---|---|---|
| SQVM NE | Saquinavir mesylate | Water, Camul MCM (4–8%), Tween 80 (6–15,75%) e PEG 400 (2–5,25%) | Neuro-AIDS | Intravenous | Mahajan et al., 2014 |
| Lf-IDV-NEs | Indinavir and Lactoferrin | IDV (0.2%), oleic acid (0.32% w / v), α-tocopherol (0.25% w / v), was added to olive oil (7.45% w / v) | HIV | Intravenous | Karami et al., 2019 |
| CUR NE | Curcumin | CUR (95%) Purity, SPC, Tween 80, tocol acetate | Sepsis | Intravenous | Shukla et al., 2014 |
| CLN | Cefuroxime | Cefuroxime (0.3%, w / w) mixture of oil (10%, w / w) and lecithin (3%, w / w), Tween 80 (0.8%, w / w), glycerol (2, 3% w / w) and sodium oleate (0.1%) | Meningitis | Intravenous | Harun et al., 2018 |
| Baicalin NE | Baicalin | Isopropyl myristate phosphatidylcholine, propylene glycol, distilled water (27.3: 31.8: 31.8: 9.1 (w / w) | HBV | Oral | Xu et al., 2019a, Xu et al., 2019b |
| NE | Amoxicilin | Water, (4 mL) with chitosan (0.6 mg / ml) and heparin (0.2 mg / ml), oily paraffin oil phase (80 mL) containing 1.2 mL of a Span20: Tween20 in a proportion 75:25. | Úlcer | Oral | Lin et al., 2012 |
| NE | Thiazoline | oleic acid (2.75 g), paraben in a 6% (w / v) solution of methylparaben and 3% (w / v) of propylparaben in propylene glycol (0.22 g), butylhydroxyanisole (0.001 g) 0, Solutol HS 15 (1.5 g) as an organic phase plus ultrapure water (5.97 g) that made up the aqueous phase. | Malária | Oral | Silva et al., 2020 |
| NE02 | Oligonucleotide CpG |
Double-chain cationic surfactant (DODAC), class B oligonucleotide - murine TLR9 agonist (TLR9 / CpG - ODN 1826), sterile water | H5N1 | Intramuscular | WANG et al., 2020 |
| Rif NE | Rifampicin | rifampicin (0.1% w / w), oleic acid (1.0% w / w), polysorbate 80 (0.9% w / w) Mili-Q water |
Ocular tuberculosis | eyepiece | Henostroza et al., 2020 |
| NE2b | acyclovir | Water (w / w), ACV 0.25% w / w, polaxamer 407 15.3% (w / w), polaxamer 188 1.33% (w / w) Transcutol®P (w / w), Triacetin (w / w) | Herpes | eyepiece | Mahboobian et al., 2020 |
NE (Nanoemulsion); SQVM NE (Nanoemulon carried with siquinavir mesylate); Lf-IDV-NEs (idinavir and lactoferrin nanoemulsion); CUR NE (Curcumin Nanoemulsion); CLN (cefuroxime nanoemulsion); Baicalin NE (baicalin nanoemulsion; HBV (chronic hepatitis B); HIV (human immunodeficiency virus); Neuro AIDS (acquired immunodeficiency syndrome); NE2b (acyclovir nanoemulsion); NE02 (nanoemulsion) containing oligonucleotide CpG); Rif NE (Ripamficin Nanoemulsion).