Table 9.
Polymeric nanoparticles applied to the treatment of systemic infections.
| Formulation | Active principle | Composition | Therapeutic target | Route of administration | Reference |
|---|---|---|---|---|---|
| AMB- PNs | Amphotericin B (AmB) | Diblock copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) (PLGA-TPGS) | Candida albicans | intravenous | Tang et al., 2014 |
| PLGA PNs | Amphotericin B (AmB) | poly (D, L-lactide-co-glycolide) (PLGA), AmB, DMSO or DMSO/acetone (1:1), PVA (stabilizing solution) | Aspergillus fumigatus | intraperitoneal | Van de Ven et al., 2012 |
| Esc_ Fluo- PNs | peptide Esc | poly (D, L-lactide-co-glycolide) (PLGA, peptide Esc, methylene chloride, ethanol | Pseudomonas aeruginosa | intratracheal | Casciaro et al., 2019 |
| CNPs-KAg | SwIAV H1N2 antigens | Chitosan, SwIAV H1N2, acid acetic, | Virulent SwIAV | intranasally | Dhakal et al. 2018 |
| y3-PLGA/S + T NPs | Sparfloxacin and Tacrolimus | PLGA, dichoromethane (DCM), Bovine serum albumin, y3 peptide | Pseudomonas aeruginosa | intratracheal | Yang et al. 2020 |
| BNZ-nps | Benznidazole | Lutrol® F-68 (P188), Benznidazole, ethanol | Trypanosoma cruzi | oral | Scalise et al. 2016 |
| Meropenem-loaded nanoparticles | Meropenem | Chitosan, acetic acid, Meropenem | Klebsiella pneumoniae | intraperitoneally | Abdelkader et al. 2017 |
| IVM CS-ALG | Ivermectin | Chitosan, alginate, acetic acid solution | Brugia malayi | subcutaneously | Ali et al., 2013 |
PNs: Polymeric nanoparticles; AMB/AmB: amphotericin B; AMB-NPs - Amphotericin B polymeric nanoparticle with Dibloco copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly (ε-caprolactone glycolide) succinate; PLGA-TPGS: Diblock copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide); PLGA: poly(d, l-lactide-co-glycolide); PLGA PNs – Polymeric nanoparticle of poly (lactide-co-glycolide) with amphotericin B; DMSO: dimethyl sulfoxide; PVA: polyvinyl alcohol; Esc_ Fluo-NPs: rhodamine-labeled NPs loaded with Esc(1–21); BNZ: Benznidazole; BNZ-nps: polymeric nanoparticles with benznidazole; IVM CS-ALG: chitosan-alginate nanoparticles with ivermectin; CNPs-KAg: - Killed SwIAV H1N2 (δ-lineage) antigens were encapsulated in chitosan polymer-based nanoparticle; SwIAV H1N2: Influenza A virus; y3-PLGA/S + T NPs – Polymeric nanoparticle of poly (lactide-co-glycolide) with Sparfloxacin and tacrolimus and conjugated with y3 peptide; DCM: dichoromethane; P188: Lutrol® F-68.