Table 10.
Hydrogels applied to the treatment of systemic infections.
| Formulation | Drug | Composition | Therapeutic target | Route of administration | Reference |
|---|---|---|---|---|---|
| Mucoadhesive thermo-responsive systems | Propolis | Polaxamer 407 + Carbopol 934P | Candida spp | vaginal | Pereira et al., 2013 |
| Hydrogel | Cyclocyclin/gentamicin | Agarose | Staphylococcus aureus | Topical | Grolman et al., 2019 |
| Hydrogel | Vancomycin | Oligo(poly(ethylene glycol)fumarate/sodium metacrylate | Staphylococcus aureus | Topical | Gustafson et al.,2016 |
| Injectable mucoadhesive hydrogel | Amoxicilin | Chitosan-grafted-dihydrocaffeic acid + oxidized pullulan |
Staphylococcus aureus Escherichia coli |
Intravenous | Liang et al., 2018 |
| Injetable hydrogel | Lisostaffin | Polyethylene glycol | Staphylococcus aureus | Intravenous | Johnson et al.,2018 |
| Gastro-mucoadhesive hydrogel | Acyclovir | Cholestyramine resin/sodium alginate/carbopol | Herpes Simplex virus | Oral | Jain et al.,2015 |