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Pharmacokinetic/pharmacodynamic model observed-predicted fit for isolate CTAP23. (A) Amikacin pharmacokinetic data. (B and C) Total bacterial population observed versus predicted values for the population (B) and posterior (C) estimates. (D and E) Resistant bacterial population observed versus predicated values for the population (D) and posterior (E) estimates. Doses of 15 mg/kg (circles), 25 mg/kg (triangles), and 50 mg/kg (squares); ELF exposure (hexagons); and control (diamonds).
