TABLE 4.
Pharmacokinetic/pharmacodynamic exposures required for bacterial stasis, 1-log, and 2-log reduction in the total bacterial burden over 24 ha
| Isolate | Infection site | Exposure target | Stasis (log10 CFU/ml) | 1-log kill (log10 CFU/ml) | 2-log kill (log10 CFU/ml) |
|---|---|---|---|---|---|
| CTAP40 | Blood | fAUC | 108.81 | 124.70 | 174.95 |
| fAUC/MIC | 13.60 | 15.59 | 21.87 | ||
| fCmax | 24.73 | 25.86 | 27.15 | ||
| fCmax/MIC | 3.09 | 3.23 | 3.39 | ||
| ELF | fAUC | 328.21 | 342.69 | 366.42 | |
| fAUC/MIC | 41.03 | 42.84 | 45.80 | ||
| fCmax | 42.41 | 47.47 | 54.17 | ||
| fCmax/MIC | 5.30 | 5.93 | 6.77 | ||
| CTAP23 | Blood | fAUC | 117.54 | - | - |
| fAUC/MIC | 58.77 | ||||
| fCmax | 26.41 | - | - | ||
| fCmax/MIC | 13.21 | ||||
| ELF | fAUC | 342.92 | 688.54 | 688.82 | |
| fAUC/MIC | 171.46 | 344.27 | 344.1 | ||
| fCmax | 47.04 | 42.40 | 47.81 | ||
| fCmax/MIC | 23.52 | 21.20 | 23.91 |
a
-, no threshold was identified.