TABLE 5.

Probability of achieving either bacterial stasis, a 1-log reduction, or 2-log reduction in the total bacterial population within 24 h of commencing intravenous amikacin

Isolate	Infection site	Dose in mg/kg	Renal function (ml/min)	Stasis (log10 CFU/ml)	1-log kill (log10 CFU/ml)	2-log kill (log10 CFU/ml)
CTAP40	Blood	15	60	1	1	1
		30	60	1	1	1
		50	60	1	1	1
		15	100	1	0.99	0.89
		30	100	1	1	1
		50	100	1	1	1
		15	140	0.90	0.52	0.16
		30	140	1	1	1
		50	140	1	1	1
	ELF	15	60	0	0	0
		30	60	0.93	0.44	0.03
		50	60	1	1	1
		15	100	0	0	0
		30	100	0.41	0.03	0
		50	100	1	1	1
		15	140	0	0	0
		30	140	0.02	0	0
		50	140	1	1	1
CTAP23	Blood	15	60	1	0	0
		30	60	1	0	0
		50	60	1	0	0
		15	100	0.99	0	0
		30	100	1	0	0
		50	100	1	0	0
		15	140	0.69	0	0
		30	140	1	0	0
		50	140	1	0	0
	ELF	15	60	0	0	0
		30	60	0.57	0	0
		50	60	1	0	0
		15	100	0	0	0
		30	100	0.06	0	0
		50	100	1	0	0
		15	140	0	0	0
		30	140	0	0	0
		50	140	1	0	0