. 2020 Aug 20;64(9):e00402-20. doi: 10.1128/AAC.00402-20

TABLE 4.

Sets of sequential isolates from single patients that demonstrated a susceptible (S)-to-nonsusceptible (I or R) shift in antimicrobial resistance within a 6-month period, representing a single infection episode

Organism and patient ID	Specimen ID	Specimen source	Interval (no. of days)	FLU^a		VORI^a		CASP^a		MICA^a		ANI^a		ST^a	Molecular mechanism of resistance
Organism and patient ID	Specimen ID	Specimen source	Interval (no. of days)	MIC	Resistance	MIC	Resistance	MIC	Resistance	MIC	Resistance	MIC	Resistance	ST^a	Molecular mechanism of resistance
C. albicans
PA0188	SP0206	Blood	0	0.5	S	≤0.008	S							918	Unknown
PA0188	SP0369	Pleural fluid	83	≥256	R	8	R							918
PA2062	SP2512	Blood	0	2	S	0.015	S							726	ERG3: A255T
PA2062	SP2683	Blood	55	256	R	8	R							726
PA0909	SP1153	Blood	0					0.06	S	0.015	S	≤0.015	S	3568	GSC1: S645P
PA0909	SP1274	Blood	55					>8	R	2	R	0.25	S	3568	GSC1: S645P
PA1070	SP1261	Blood	0					0.5	I	0.06	S	0.06	S	3570	GSC1: S645P
PA1070	SP1350	Peritoneal fluid	34					4	R	2	R	0.5	I	3570	GSC1: S645P
PA3104	SP4920	Blood	0					0.12	S	0.015	S	≤0.015	S	3569	GSC1: S645P
PA3104	SP5052	Blood	39					8	R	4	R	1	R	3569	GSC1: S645P
C. glabrata
PA1293	SP1533	Abscess	0					0.06	S					10	None detected
PA1293	SP1643	Abdomen	35					0.5	R					10	None detected
PA3825	SP4776	Blood	0					0.06	S
PA3825	SP4784	Blood	2					0.25	I
PA1823	SP2186	Blood	0					0.03	S
PA1823	SP2198	Blood	5					0.25	I
PA2095	SP2554	Urine	0					0.06	S
PA2095	SP2585	Urine	9					0.25	I
PA3539	SP4419	Pleural fluid	0					0.06	S
PA3539	SP4650	Pleural fluid	80					0.25	I
PA1563	SP1866	Peritoneal fluid	0							0.015	S
PA1563	SP2187	Blood	115							0.12	I
PA1188	SP1405	Blood	0					0.12	S			0.12	S
PA1188	SP1475	Blood	26					0.25	I			0.25	I
PA1921	SP2320	Blood	0					0.12	S	0.03	S	0.03	S	16	FKS2: S663P
PA1921	SP2659	Blood	118					8	R	2	R	2	R	16	FKS2: S663P
PA2117	SP2583	Blood	0					0.12	S	0.015	S	0.03	S
PA2117	SP2672	Blood	28					1	R	0.5	R	1	R
PA2320	SP3417	Blood	0					0.06	S	0.015	S	0.03	S	3	FKS2: S663P
PA2320	SP3689	Blood	75					8	R	8	R	2	R	3	FKS2: S663P
PA2472	SP3046	Blood	0					0.12	S	0.015	S	0.06	S	19	FKS2: S663P
PA2472	SP3439	Blood	127					0.25	I	0.12	I	0.5	R	19	FKS2: S663P
PA2419	SP2982	Peritoneal fluid	0					0.06	S	0.015	S	≤0.015	S	17
PA2419	SP3003	Blood	10					0.5	R	0.12	I	0.25	I	3	FKS1: F625I
C. parapsilosis
PA1947	SP2355	Wound	0			0.12	S
PA1947	SP2398	Other	17			0.25	I
PA2106	SP2568	Blood	0			0.06	S
PA2106	SP2675	Blood	35			0.25	I
C. tropicalis
PA3063	SP3823	Blood	0			0.12	S
PA3063	SP3887	Blood	25			0.25	I
PA3762	SP4694	Peritoneal fluid	0	1	S	0.12	S							975	Aneuploidy of supercontig 3.8 and increased copy no. of ERG11 and TAC1
PA3762	SP4785	Peritoneal fluid	28	32	R	2	R							975
PA3550	SP4433	Blood	0					0.06	S	0.015	S	0.12	S	974	CTRG_04661: S30P
PA3550	SP4501	Blood	22					8	R	2	R	1	R	974	CTRG_04661: S30P
C. krusei
PA1488	SP1777	Blood	0					0.25	S
PA1488	SP1811	Blood	15					0.5	I

FLU, fluconazole; VORI, voriconazole; CASP, caspofungin; MICA, micafungin; ANI, anidulafungin; ST, sequence type.