TABLE 2.
Summary of final model parametersa
| Parameter | Estimate (%RSE) | Shrinkage (%) | Bootstrap median (90% CI) |
|---|---|---|---|
| θCL day 1 (liter/h) | 0.563 (6.7) | 0.558 (0.495–0.618) | |
| θCL day 2 (liter/h) | 0.737 (6.1) | 0.734 (0.668–0.817) | |
| θCL day 3 (liter/h) | 1.01 (9.1) | 1.00 (0.854–1.17) | |
| θV1 day 1(liter) | 6.04 (7.0) | 6.02 (5.39–6.75) | |
| θV1 day 2 (liter) | 7.32 (5.3) | 7.28 (6.56–8.09) | |
| θV1 day 3 (liter) | 7.70 (5.3) | 7.64 (6.83–8.62) | |
| θQ (liter/h) | 1.31 (15.7) | 1.31 (1.03–1.76) | |
| θV2 (liter) | 5.13 (13.7) | 5.18 (4.04–6.49) | |
| Interindividual variability | |||
| ω2CL (%CV) | 24.7 (27.3) | 1.7 | 0.243 (0.184–0.296) |
| ω2V1 (%CV) | 28.2 (39.6) | 4.1 | 0.274 (0.182–0.356) |
| ω2Q (%CV) | 0 FIX | ||
| ω2V2 (%CV) | 49.4 (37.1) | 17.4 | 0.502 (0.327–0.690) |
| corCL-V1 | 0.868 (34.9) | 0.886 (0.611–1.00) | |
| Residual error model | |||
| σ2prop (%CV) | 19.9 (4.4) | 0.195 (0.181–0.209) |
a
Terms: σ2prop, variance of proportional residual random error; RSE, relative standard error; %CV, percent coefficient of variation; CL, clearance; Q, intercompartmental clearance; V1, volume of distribution of the central compartment; V2, volume of distribution of the peripheral compartment; cor, correlation; 90% CI, 90% confidence interval of the parameter estimate derived from a nonparametric bootstrap analysis (n = 1,000).