TABLE 3.

Probability of target attainment of caspofungin for C. albicans, C. glabrata, and C. parapsilosis by MIC values based on preclinical targets and clearance values estimated for 3 days of therapy with confidence intervals based on bootstrap samples^a

Organism and PTA variable	PTA data determined at various caspofungin MICs and times after the first dose of caspofungin
	0.016 mg/liter			0.032 mg/liter			0.064 mg/liter			0.125 mg/liter			0.25 mg/liter			0.5 mg/liter			1 mg/liter
	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3	Day 1	Day 2	Day 3
C. albicans
Median	100.0	100.0	100.0	100.0	100.0	98.7	97.0	79.6	34.4	22.7	3.2	0.2	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
5th percentile	100.0	100.0	100.0	100.0	99.8	98.0	96.1	77.6	32.4	20.6	2.3	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
95th percentile	100.0	100.0	100.0	100.0	100.0	99.2	97.9	81.6	36.9	24.8	4.1	0.5	0.3	0.0	0.0	0.1	0.0	0.0	0.0	0.0	0.0
C. glabrata
Median	100.0	100.0	100.0	100.0	100.0	100.0	100.0	99.9	98.0	96.6	77.7	32.1	18.2	2.2	0.1	0.1	0.0	0.0	0.0	0.0	0.0
5th percentile	100.0	100.0	100.0	100.0	100.0	100.0	100.0	99.8	97.3	95.6	75.6	30.1	16.4	1.5	0.0	0.1	0.0	0.0	0.0	0.0	0.0
95th percentile	100.0	100.0	100.0	100.0	100.0	100.0	100.0	100.0	98.8	97.5	79.9	34.5	20.2	3.0	0.4	0.2	0.0	0.0	0.1	0.0	0.0
C. parapsilosis
Median	100.0	100.0	100.0	99.9	98.7	85.6	75.4	33.1	5.3	2.5	0.1	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
5th percentile	100.0	100.0	99.9	99.8	98.1	83.8	73.2	30.8	4.2	1.7	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
95th percentile	100.0	100.0	100.0	100.0	99.3	87.4	77.6	35.6	6.6	3.4	0.3	0.0	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

^aPTA, probability of target attainment.