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Concentration- and time-dependent antimicrobial activity of AA139, AA139-PNP, or AA139-MCL against K. pneumoniae ESBL. Bacterial cultures of K. pneumoniae ESBL were exposed to 2-fold increasing concentrations of free AA139, AA139-PNP, or AA139-MCL for 24 h at 37°C under shaking conditions. Shown are the median ± range of triplicate experiments. The dashed gray line indicates the lower limit of quantification being log 0.7.
