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Therapeutic efficacy of AA139, AA139-PNP, or AA139-MCL in rats with ESBL pneumonia-septicemia. At 24 hours after initiation of infection, groups of 12 rats were treated once-daily (q24h) for 10 days with free AA139, AA139-PNP, or AA139-MCL. Shown are the survival curves (Kaplan-Meier) representing rats reaching humane endpoints. MTD, maximum tolerated dose; MFD, maximum feasible dose.
