TABLE 1.
Limiting dose of AA139, AA139-PNP, or AA139-MCL
| Treatmenta | Limiting dose (mg/rat) [mg/kg] | Dose-limiting toxicity |
|---|---|---|
| AA139 | 0.25 (∼1)b | Acute toxicity (abnormal breathing) observed at 0.5 mg/rat |
| AA139-PNP | 0.5 (∼2)c | Maximum feasible dose due to technical limitations |
| AA139-MCL | 0.5 (∼2)b | Acute toxicity (abnormal breathing) observed at 1 mg/rat |
| NSS | Well tolerated at this vol |
a
Treatment was administered to groups of 11 rats via endotracheal aerosolization of a 100-μl suspension. Rats were regularly checked for signs of acute toxicity over 24 h. When no acute toxicity was observed, the dose was increased 2-fold, until acute toxicity was observed or until the dose could not be further increased due to technical limitations. MTD, maximum tolerated dose. MFD, maximum feasible dose.
b
MTD.
c
MFD.