TABLE 2.
Statistical evaluation of rat survival after treatment with AA139, AA139-PNP, or AA139-MCL
| Treatment | Treatment dose (mg) |
P value by treatmenta |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Placebo (NSS) | Unloaded |
AA139 |
|||||||
| PNP | MCL | Free | PNP |
MCL |
|||||
| 0.25 mg | 0.25 mg | 0.5 mg | 0.25 mg | 0.5 mg | |||||
| Placebo (NSS) | |||||||||
| Unloaded-PNP | 0.9329 | ||||||||
| Unloaded-MCL | 0.9689 | 0.9778 | |||||||
| AA139 | 0.25 | 0.9772 | 0.9879 | 0.9747 | |||||
| AA139-PNP | 0.25 | 0.0911 | 0.1218 | 0.1680 | 0.1208 | ||||
| 0.5 | 0.0131 | 0.0156 | 0.0161 | 0.0079 | 0.5966 | ||||
| AA139-MCL | 0.25 | 0.0043 | 0.0074 | 0.0061 | 0.0069 | 0.1140 | 0.7208 | ||
| 0.5 | 0.0055 | 0.0068 | 0.0085 | 0.0056 | 0.0997 | 0.5966 | 0.7635 | ||
a
Statistical evaluation using the log-rank (Mantel-Cox) test of rat survival after once-daily (q24h) administration of free AA139, AA139-PNP, or AA139-MCL over 10 days. Significant P values (P < 0.05) are indicated in bold.