TABLE 5.

Characteristics of individual subjects with development of substitutions at resistance-associated positions in RSV F^a

Study and subject	RSV subtype	Baseline lymphocyte count (cells/μl)b	Time-weighted avg change in nasal RSV viral load (log10 copies/ml)c	Visit	RSV RNA (copies/ml)	Resistance-associated substitution(s)
HCT URTI (GS-US-218-0108)
1	A	<200	−1.88	Baseline	7,900,000	None
				Day 9	12,000,000	None
				Day 17	87,100	None
				Day 22	92,400	None
				Day 28	11,100	F140F/I, T400T/I
2	B	<200	−0.06	Baseline	11,000,000	None
				Day 9	81,000,000	M396M/I, S398S/L
				Day 13	54,700	T400T/A
3	A	160	−0.46	Baseline	83,000,000	None
				Day 9	12,000,000	None
				Day 17	55,000,000	None
				Day 22	532,000	S398S/L, T400T/I
				Day 28	10,900	D486D/V
4	A	480	−0.13	Baseline	28,000,000	None
				Day 9	24,000,000	None
				Day 17	199,000	D338D/Y
5	B	<200	−0.66	Baseline	54,000,000	None
				Day 9	85,000,000	K394K/R
				Day 13	18,700	None
				Day 22	3,400	Assay failure
6	B	610	0.28	Baseline	10,000,000	None
				Day 9	11,000,000	None
				Day 17	10,700	F140F/I
				Day 22	157,000	E487E/G
7	A	420	−0.25	Baseline	4,400,000	None
				Day 9	36,000	None
				Day 28	10,600	G143S
8	A	100	−0.08	Baseline	1,300,000	None
				Day 9	4,200	None
				Day 17	47,600	L141L/F
				Day 28	3,400	L141F
9	B	<200	−0.03	Baseline	10,000,000	None
				Day 9	93,200	L141W
				Day 13	14,100	None
10	A	<200	−0.51	Baseline	69,000,000	None
				Day 9	18,000,000	None
				Day 17	2,900,000	T400T/I
				Day 28	4,300	None
				Day 42	524,000	T400I
				Day 49	902,000	None
				Day 56	33,900	None
HCT LRTI (GS-US-218-1502)
1	A	1,140	1.19	Baseline	40,600	None
				Day 9	419,000	None
				Day 28	4,200	D486V
2	A	180	−0.24	Baseline	15,000,000	None
				Day 9	8,900,000	None
				Day 22	3,800,000	None
				Day 56	5,400,000	T400I
3	B	400	−0.44	Baseline	28,000,000	None
				Day 9	23,000,000	None
				Day 22	7,400,000	L141L/F
				Day 28	54,000	L141F
4	B	1,000	−0.98	Baseline	42,000,000	None
				Day 9	7,800	None
				Day 22	11,000,000	D486E
				Day 28	290,000	D486E
5	A	270	−0.49	Baseline	28,000,000	None
				Day 9	1,600,000	None
				Day 28	1,100,000	D486D/N
6	B	270	1.44	Baseline	6,200	None
				Day 7	2,100,000	S398L
				Day 17	134,000	T400I
Lung transplant (GS-US-218-1797)
1	A	370	0.60	Baseline	13,000,000	None
				Day 7	52,000,000	None
				Day 9	8,300,000	None
				Day 21	307,000	D486D/V
				Day 28	16,500	T400I
Hospital inpatients (GS-US-218-1227)
1	A	430	0.11	Baseline	1,700,000	None
				Day 5	6,000,000	None
				Day 14	5,100	L138L/I

^aHCT, hematopoietic cell transplant; LRTI, lower respiratory tract infection; RSV, respiratory syncytial virus; URTI, upper respiratory tract infection.

^bLymphocyte count is listed as <200 cells/μl when the patient was recorded as lymphopenic for stratification but the exact lymphocyte count was not recorded.

^cFrom baseline to day 9 for HCT recipients, day 7 for lung transplant recipients, and day 5 for hospitalized patients.