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. 2020 Aug 20;64(9):e00836-20. doi: 10.1128/AAC.00836-20

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Copyright © 2020 Squires et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — ATI-2173 is a potent and selective inhibitor of all HBV genotypes. (A) ATI-2173 inhibits HBV in HepG2 cells with an EC₅₀ of 0.26 μM. (B) ATI-2173 inhibits HBV in primary human hepatocytes (PHHs) with an EC₅₀ of 1.31 nM. (C) ATI-2173 is not genotype selective. (D) Summary of EC₅₀ by genotype. GenBank IDs (left) correspond to the validated lab strains used in this assay.