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Plasma analyte concentration from rats dosed with equimolar single oral doses of ATI-2173 (50 mg/kg) or clevudine (25 mg/kg). (A) Plasma was isolated over 24 h and assessed for unphosphorylated clevudine. Tissues were collected at different time points following dosing and assessed for 5′-tripohosphate in the liver (B), unphosphorylated clevudine in skeletal muscle (C), or 5′-triphosphate in skeletal muscle (D).
