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Combination effect of ATI-2173 plus other anti-HBV compounds on HBV activity in primary human hepatocytes.
| Compound combined with ATI-2173 | Combination indexa | Combination effect |
|---|---|---|
| Entecavir | 38.62 | Minor synergism |
| GLS4 | 7.59 | Additive |
| Lamivudine | −5.86 | Additive |
| Tenofovir | 8.56 | Additive |
| Adefovir | 32.85 | Minor synergism |
A combination index of <25 is considered additive, while 25 to 50 is considered minor synergism.
