FIG 4.
Pharmacokinetic simulation of ivermectin concentration-time profile when given at 0.3, 0.6, and 1.2 mg/kg for 7 days in rhesus macaques. Illustrates the simulation of plasma ivermectin concentration-time profile. One-compartment analysis best described the observed data by using the estimates calculated by noncompartmental analysis following the first and seventh doses as initial estimates. In the simulation, Cmax had mean estimates of 150, 300, and 600 ng/ml at approximately 4 h after the first dose and reached a steady state around the fifth dose with Cmax at 243, 486, and 973 ng/ml at the ivermectin doses 0.3, 0.6, and 1.2 mg/kg, respectively. IVM, ivermectin.