TABLE 1.
In vitro antiplasmodial activity and cytotoxicity of epirubicina
| Drug | EC50 (nM) of P. falciparum strain: |
COS-7 |
HepG2 |
||||
|---|---|---|---|---|---|---|---|
| 3D7 | Dd2 | W2 | CC50 (nM) | SI | CC50 (nM) | SI | |
| Epirubicin | 110.7 ± 22.4 | 99.5 ± 25.1 | 68.9 ± 5.1 | 5,480 ± 720 | 49.4 | 80 ± 30 | 0.7 |
| Chloroquine | 11.3 ± 3.6 | 137.8 ± 34.1 | 182.8 ± 11.5 | ND | ND | ND | ND |
a
EC50, half of the maximal inhibitory concentration in P. falciparum; CC50, half of the maximal cytotoxic concentration in mammalian cells; SI, selectivity index calculated from CC50/EC50 (3D7); ND, not determined. Data are means ± SD and are derived from three independent experiments.