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. 2020 Aug 20;64(9):e00152-20. doi: 10.1128/AAC.00152-20

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Copyright © 2020 Van den Kerkhof et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — Comparison of in vitro intracellular amastigote (A and C) and extracellular promastigote (B and D) susceptibility to the selected AP series between the wild-type parent (LEM3323Cl₄) and the successfully cultured adapted clones of the DNDI-1044-selected (A and B) and DNDI-8012-selected (C and D) resistant lines. Results are expressed as the mean IC₅₀ ± SEM and are based on two independent replicates run in duplicate (*, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001). For DNDI-8012-generated clones, only a few clones were selected for amastigote susceptibility assessment.