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. 2020 Aug 20;64(9):e00152-20. doi: 10.1128/AAC.00152-20

TABLE 1.

In vitro susceptibility of intracellular amastigotes to DNDI-1044 after each in vitro selection cycle^a

Cycle	Mean IC₅₀ (μM) ± SEM
Cycle	ITMAP263	LEM4038
Wild type	0.19 ± 0.08	0.35 ± 0.07
Cycle 1	0.21 ± 0.02	0.43 ± 0.08
Cycle 2	0.60 ± 0.07	0.27 ± 0.04
Cycle 3	0.45 ± 0.09	0.36 ± 0.11
Cycle 4	0.53 ± 0.15	0.56 ± 0.17
Cycle 5	0.24 ± 0.08	0.86 ± 0.30

^a

The results are based on two independent replicates run in duplicate.