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Plot of the residual activities (expressed as percentages) of the CphA and YEM-1 enzymes against increasing Zn(II) (A), Co(II) (B), and Cd(II) (C) concentrations. In the presence of Zn ions, the apparent dissociation constant was measured as described in Materials and Methods. Each point represents the average of three measurements made with 100 μM imipenem. The enzyme concentrations were 0.5 and 1 nM for CphA and YEM-1, respectively.
