TABLE 1.
Comparison of baseline characteristics and treatment modalities for patients who failed treatment compared to patients who did not fail treatment after at least 56 days of antibiotics in the Barwon Health cohort from 1998 to 2018
| Characteristic | Total no. (% of total) | No. of failures (% of treated) | No. of successes (% of treated) | P value (comparing failure vs success) |
|---|---|---|---|---|
| Gender | ||||
| Male | 244 (56.7) | 7 (2.9) | 237 (97.1) | 0.02 |
| Female | 186 (43.3) | 0 (0.0) | 186 (100.0) | |
| Median Age (years [IQR]) | 58 (33–75) | 73 years (43–79) | 58 (33–75) | 0.42 |
| Weight (kg) | ||||
| <60 | 33 (7.7) | 1 (3.0) | 32 (97.0) | <0.001 |
| 60–90 | 150 (34.9) | 0 (0.0) | 150 (100.0) | |
| >90 | 56 (13.0) | 6 (10.7) | 50 (89.3) | |
| Missing | 191 (44.4) | 0 (0.0) | 191 (100.0) | |
| Lesion type | ||||
| Ulcer | 354 (82.3) | 6 (1.7) | 348 (98.3) | 0.44 |
| Nodule | 18 (4.2) | 1 (5.6) | 17 (94.4) | |
| Edema | 53 (12.3) | 0 (0.0) | 53 (100.0) | |
| Plaque | 5 (1.2) | 0 (0.0) | 5 (100.0) | |
| WHO category | ||||
| 1 | 285 (66.3) | 3 (1.1) | 282 (99.0) | 0.35 |
| 2 | 89 (20.7) | 2 (2.3) | 87 (97.8) | |
| 3 | 56 (13.0) | 2 (3.6) | 54 (96.4) | |
| Size (mm2) | ||||
| ≤400 | 60 (20.3) | 0 (0.0) | 60 (100.0) | 0.41 |
| 401–1,600 | 139 (47.0) | 3 (2.2) | 136 (97.8) | |
| >1,600 | 97 (32.8) | 3 (3.1) | 94 (96.9) | |
| Median duration of symptoms (days [IQR]) | 42 (28–67) | 30 (28–60) | 42 (28–70) | 0.60 |
| Lesion location | ||||
| Upper limb | 126 (29.3) | 1 (0.8) | 125 (99.2) | 0.64 |
| Lower limb | 299 (69.5) | 6 (2.0) | 293 (98.0) | |
| Head/trunk | 5 (1.2) | 0 (0.0) | 5 (100.0) | |
| Multiple lesions | ||||
| No | 395 (91.9) | 6 (1.5) | 389 (98.5) | 0.55 |
| Yes | 35 (8.1) | 1 (2.9) | 34 (97.1) | |
| Diabetes | ||||
| No | 390 (90.7) | 7 (1.8) | 383 (98.2) | 0.39 |
| Yes | 40 (9.3) | 0 (0.0) | 40 (100.0) | |
| Immune suppression | ||||
| No | 296 (92.1) | 5 (1.3) | 391 (98.7) | 0.04 |
| Yes | 34 (7.9) | 2 (5.9) | 32 (94.1) | |
| Median eGFR (ml/min [IQR]) | 86 (69,101) | 73 (54,92) | 86 (69,101) | 0.26 |
| Antibiotic regimen | ||||
| Rifampin-clarithromycin | 269 (62.6) | 7 (2.6) | 262 (97.4) | 0.05 |
| Rifampin-fluoroquinolone | 147 (34.2) | 0 (0.0) | 147 (100.0) | |
| Median antibiotic duration (days [IQR]) | 56 (56–80) | 56 (56–70) | 56 (56–81) | 0.46 |
| Paradoxical reaction | ||||
| Yes | 160 (37.2) | 4 (2.5) | 156 (97.5) | 0.27 |
| No | 270 (62.8) | 3 (1.4) | 267 (98.9) | |
| Corticosteroid use | ||||
| Yes | 66 (15.4) | 2 (3.0) | 64 (96.7) | 0.33 |
| No | 364 (84.7) | 5 (1.4) | 359 (98.6) | |
| Surgery | ||||
| Yes | 139 (32.3) | 0 (0.0) | 139 (100.0) | 0.07 |
| No | 291 (67.7) | 7 (2.4) | 284 (97.6) |