TABLE 2.
FKS HS mutations in relation to caspofungin and micafungin MIC distribution
| Drug and polymorphism | % of isolates in the following MIC categorya: |
No. of isolates at the following determined MIC value (μg/ml): |
Total no. of isolates | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S | I | R | ≤0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | ≥16 | ||
| Caspofungin | |||||||||||||||
| No HS mutations | 2.1 | 64.6 | 33.3 | 1 | 31 | 16 | 48 | ||||||||
| FKS1 S629P | 0 | 0 | 100 | 1 | 1 | ||||||||||
| FKS2 S663P | 0 | 0 | 100 | 2 | 5 | 1 | 1 | 9 | |||||||
| Micafungin | |||||||||||||||
| No HS mutations | 100 | 0 | 0 | 34 | 14 | 48 | |||||||||
| FKS1 S629P | 0 | 0 | 100 | 1 | 1 | ||||||||||
| FKS2 S663P | 66.7 | 11.1 | 22.2 | 5 | 1 | 1 | 2 | 9 | |||||||
a
S, susceptible; I, intermediate; R, resistant.