TABLE 2.
Primary, secondary, and other predefined endpointsa
| Endpoint | Median (IQR) or no. (%) |
P value | |
|---|---|---|---|
| Pre-AXDX group (n = 84) | Post-AXDX group (n = 89) | ||
| Time to first antibiotic intervention (h) | 26.3 (4.5–43.6) | 8 (6.5–11.3) | 0.003 |
| Time to most targeted therapya (h) | 14.4 (0–49.6) | 9.0 (0–18.5) | 0.03 |
| 14-day mortality | 3 (3.6) | 0 | 0.11 |
| Hospital LOS (days) | 8 (6–10.75) | 6 (4.5–8.5) | 0.002 |
| Hospital LOS post-positive BCb (days) | 6 (4–9) | 5 (3–7) | 0.01 |
| ICU LOS post-positive BC (days) | 3 (2–6.25) | 2 (2–2.5) | 0.25 |
| Antibiotic intensity scorec | 16 (10.5–20) | 12 (9–15.5) | 0.0002 |
| 30-day readmission | 7 (8.6) | 5 (5.6) | 0.44 |
| Broad-spectrum antibiotics (days) | 3 (2–3) | 1 (0.5–2) | <0.0001 |
After positive blood cultures.
BC, blood cultures.
Calculated at 96 h of antibiotic therapy.