TABLE 3.

Metabolic stability of test compounds in human and mouse liver microsomes

Compound	Species	Assay format	% remaining at:
			0 min	15 min	30 min	45 min	60 min
Verapamil	Human	With NADPH	100.00	28.59	11.61	5.43	3.23
		Without NADPH	100.00	99.39	100.00	95.15	93.33
	Mouse	With NADPH	100.00	14.64	4.72	1.79	1.04
		Without NADPH	100.00	79.63	91.36	90.12	96.91
SB-AF-1002	Human	With NADPH	100.00	94.84	78.13	74.92	73.06
		Without NADPH	100.00	100.00	93.85	86.15	82.31
	Mouse	With NADPH	100.00	58.09	30.37	19.43	11.96
		Without NADPH	100.00	100.82	81.07	84.43	86.89