TABLE 4.
Papp value of SB-AF-1002 compared to those of cyclosporine and caffeine in monkey BBB kit
Drug | Time (min) | Papp (10−6 cm/s) |
---|---|---|
Cyclosporine | 5 | 1 |
Cyclosporine | 15 | 1 |
Cyclosporine | 30 | 1 |
Caffeine | 5 | 20 |
Caffeine | 15 | 25 |
Caffeine | 30 | 25 |
SB-AF-1002 | 5 | 6 |
SB-AF-1002 | 15 | 2 |
SB-AF-1002 | 30 | 1.1 |