TABLE 2.
In vitro susceptibilities of dematiaceous fungi isolates to anidulafungin, micafungin, and caspofungin as determined by the CLSI methods
| Species (no. of strains) | Test agent | MEC (μg/ml) |
|||
|---|---|---|---|---|---|
| Range | MEC50 | MEC90 | GMEC | ||
| Fonsecaea pedrosoi (16) | Anidulafungin | 0.5–4 | 2 | 4 | 1.43 |
| Micafungin | 0.25–4 | 2 | 4 | 1.31 | |
| Caspofungin | 0.125–4 | 2 | 4 | 1.03 | |
| Exophiala dermatitidis (12) | Anidulafungin | >4 | >4 | >4 | >4 |
| Micafungin | >4 | >4 | >4 | >4 | |
| Caspofungin | >4 | >4 | >4 | >4 | |
| Exophiala jeanselmei (9) | Anidulafungin | 0.5–4 | |||
| Micafungin | 0.5–4 | ||||
| Caspofungin | 1–4 | ||||
| Exophiala spinifera (10) | Anidulafungin | 0.25–2 | 0.5 | 1 | 0.68 |
| Micafungin | 0.03–0.25 | 0.125 | 0.25 | 0.11 | |
| Caspofungin | 0.125–1 | 0.25 | 0.5 | 0.26 | |
| Phialophora verrucosa (11) | Anidulafungin | 0.125–4 | 1 | 2 | 1.02 |
| Micafungin | 0.06–2 | 0.5 | 1 | 0.53 | |
| Caspofungin | 0.06–4 | 1 | 2 | 0.88 | |
| Phialophora richardsiae (4) | Anidulafungin | 0.5–2 | |||
| Micafungin | 0.5–1 | ||||
| Caspofungin | 0.25–1 | ||||
| Cladophialophora. carrionii (9) | Anidulafungin | 0.5–4 | |||
| Micafungin | 0.5–2 | ||||
| Caspofungin | 0.5–2 | ||||
| Bipolaris spicifera (5) | Anidulafungin | 0.03–0.25 | |||
| Micafungin | 0.06–0.25 | ||||
| Caspofungin | 0.125–0.5 | ||||
| Curvularia lunata (4) | Anidulafungin | 0.06–0.25 | |||
| Micafungin | 0.015–0.125 | ||||
| Caspofungin | 0.125–0.5 | ||||
| Veronaea botryosa (4) | Anidulafungin | >4 | |||
| Micafungin | >4 | ||||
| Caspofungin | >4 | ||||