TABLE 2.
Pharmacodynamic analysis of fosfomycin exposure against different isolates of carbapenem-resistant Enterobacter cloacae and Klebsiella aerogenes
| Isolate | Fosfomycin concn (mg/liter) (× MIC) that exhibited bactericidal activity in TKS |
Pharmacodynamic parameter estimates after 24 h of fosfomycin exposure |
|||||
|---|---|---|---|---|---|---|---|
| 2–4 h | 8 h | 24 h | Emax (log10 CFU/ml) | Hill slope | EC50/MIC | R2 | |
| ATCC 13047 | 128 (4×) | 2,048 (64×) | 6.288 | 1.002 | 21.353 | 0.990 | |
| ENT 276 | 16 (32×) | 512 (1,024×) | 2,048 (4,096×) | 5.942 | 0.910 | 22.380 | 0.971 |
| ENT 427 | 32 (32×) | 128 (128×) | 5.159 | 2.362 | 57.760 | 0.964 | |
| ENT 197 | 64 (32×) | 2,048 (1,024×) | 5.127 | 3.734 | 175.000 | 0.999 | |
| ENT 265a | 128 (32×) | 128 (32×) | 2,048 (512×) | 5.315 | 7.756 | 4.785 | 0.999 |
| ENT 702a | 32 (4×) | 512 (64×) | 5.133 | 1.793 | 9.305 | 0.999 | |
| ENT 1268 | 64 (4×) | 512 (32×) | 3.635 | 6.830 | 5.410 | 0.999 | |
| ENT 376 | 128 (4×) | 2,048 (64×) | 1.221 | 4.068 | 3.045 | 0.982 | |
| ENT 263 | 512 (8×) | 2.630 | 7.903 | 7.581 | 0.999 | ||
a
Klebsiella aerogenes.