TABLE 3.

Numbers of adverse events by severity and cohort^a

Reactogenicity	Cohort 1 (N = 17)				Cohort 2 (N = 15)				Cohort 3 (N = 15)
	Severity				Severity				Severity
	None (n [%])	Mild (n [%])	Moderate (n [%])	Severe (n [%])	None (n [%])	Mild (n [%])	Moderate (n [%])	Severe (n [%])	None (n [%])	Mild (n [%])	Moderate (n [%])	Severe (n [%])
Fever	16 (94.1)	0 (0)	1 (5.9)	0 (0)	13 (86.7)	2 (13.3)	0 (0)	0 (0)	13 (86.7)	1 (6.7)	1 (6.7)	0 (0)
Headache	9 (52.9)	6 (35.3)	2 (11.8)	0 (0)	9 (60.0)	5 (33.3)	1 (6.7)	0 (0)	6 (40.0)	8 (53.3)	0 (0)	1 (6.7)
Malaise	11 (64.7)	5 (29.4)	1 (5.9)	0 (0)	13 (86.7)	2 (13.3)	0 (0)	0 (0)	9 (60.0)	5 (33.3)	0 (0)	1 (6.7)
Abdominal pain	13 (76.5)	2 (11.8)	1 (5.9)	1 (5.9)	11 (73.3)	4 (26.7)	0 (0)	0 (0)	10 (66.7)	4 (26.7)	1 (6.7)	0 (0)
Nausea	5 (29.4)	11 (64.7)	1 (5.9)	0 (0)	9 (60.0)	6 (40.0)	0 (0)	0 (0)	8 (53.3)	6 (40.0)	1 (6.7)	0 (0)
Vomiting	11 (64.7)	5 (29.4)	1 (5.9)	0 (0)	12 (80.0)	3 (20.0)	0 (0)	0 (0)	14 (93.3)	1 (6.7)	0 (0)	0 (0)
Shortness of breath	16 (94.1)	1 (5.9)	0 (0)	0 (0)	14 (93.3)	1 (6.7)	0 (0)	0 (0)	15 (100.0)	0 (0)	0 (0)	0 (0)
Dizziness	10 (58.8)	7 (41.2)	0 (0)	0 (0)	13 (86.7)	2 (13.3)	0 (0)	0 (0)	12 (80.0)	3 (20.0)	0 (0)	0 (0)
Rash	15 (88.2)	2 (11.8)	0 (0)	0 (0)	13 (86.7)	2 (13.3)	0 (0)	0 (0)	13 (86.7)	1 (6.7)	1 (6.7)	0 (0)
Urticaria	16 (94.1)	1 (5.9)	0 (0)	0 (0)	15 (100.0)	0 (0)	0 (0)	0 (0)	14 (93.3)	1 (6.7)	0 (0)	0 (0)
Bloody stools	17 (100.0)	0 (0)	0 (0)	0 (0)	14 (93.3)	1 (6.7)	0 (0)	0 (0)	14 (93.3)	1 (6.7)	0 (0)	0 (0)
Any of the above symptoms	4 (23.5)	9 (52.9)	3 (17.6)	1 (5.9)	5 (33.3)	9 (60.0)	1 (6.7)	0 (0)	3 (20.0)	8 (53.3)	3 (20.0)	1 (6.7)

^aN, number of subjects in population; n, number of subjects with at least one occurrence of an adverse event in the specified category.