TABLE 2.
Comparison of infections by isolates with and without CzIE
| Characteristic | Clinical and microbiologic valuesa related to isolates: |
P value | |
|---|---|---|---|
| With CzIE (n = 36) | Without CzIE (n = 214) | ||
| Age (yrs) | 10.4 (6.9–11.9) | 9.1 (5.1–12.2) | 0.38 |
| Female gender | 13 (36.1) | 87 (40.6) | 0.71 |
| Race | 0.82 | ||
| White | 30 (83.3) | 153 (71.4) | |
| Black | 5 (13.8) | 43 (20.1) | |
| Asian | 0 | 6 (2.8) | |
| Otherb | 0 | 5 (2.3) | |
| Unknown/not disclosed | 1 (2.7) | 7 (3.3) | |
| Hispanic ethnicity | 10 (27.8) | 61 (28.5) | 1 |
| Duration of symptoms on presentation (days) | 4.5 (2–7) | 5 (3–7) | 0.52 |
| Admission CRPc (mg/dl) | 4.6 (3.8–7.7) | 6.6 (3.7–15.5) | 0.21 |
| Multifocal infection | 3 (8.3) | 7 (3.3) | 0.16 |
| Subperiosteal/intraosseous abscess | 17 (47.2) | 85 (39.7) | 0.46 |
| Maximum abscess diameterd (cm) | 2.9 (1.1–4) | 3 (1.5–5.8) | 0.3 |
| Surgical procedure performed | 20 (55.5) | 136 (63.5) | 0.36 |
| ≥2 surgical procedures performede | 2 (5.6) | 43 (20.1) | 0.04 |
| Delayed first source controlf | 5 (13.8) | 23 (10.7) | 0.57 |
| ICU admission | 1 (2.7) | 12 (5.6) | 0.7 |
| Positive blood culture | 26 (72.2) | 118 (55.1) | 0.07 |
| Duration of bacteremia (days) | 1 (1–2) | 1 (1–2) | 0.39 |
| Duration of fever after admission (days) | 3 (2–4) | 3 (2–4) | 0.37 |
| Definitive treatment with 1GC | 30 (83.3) | 159 (74.3) | 0.29 |
| Discharge on oral antibiotics | 20 (55.6) | 105 (49.1) | 0.58 |
| Length of stay (days) | 6 (5–10) | 6 (5–9) | 0.9 |
| Duration of follow-up (days) | 68 (39–494) | 77 (35–247) | 0.32 |
| Progression to chronic osteomyelitis | 5 (13.8) | 8 (3.7) | 0.03 |
| Clindamycin resistance | 9 (25) | 20 (9.3) | 0.01 |
| PVLg positive | 5 (13.8) | 47 (21.9) | 0.38 |
| Vancomycin MIC of >1 μg/ml | 12 (33.3) | 100 (46.7) | 0.15 |
| agrIh | 13 (36.1) | 140 (65.4) | 0.001 |
| agrII | 2 (5.6) | 31 (14.5) | 0.19 |
| agrIII | 19 (52.7) | 21 (9.8) | <0.001 |
| agrIV | 1 (2.7) | 8 (3.7) | 1 |
| agr nontypeable | 1 (2.7) | 14 (6.5) | 0.7 |
a
All continuous variables are presented as medians with interquartile ranges; categorical variables are presented as n (%).
b
Other with regard to race includes Native American/Alaskan Native, Native Hawaiian/Pacific Islander, and self-identified multiple races.
c
CRP, C-reactive protein.
d
Only 61 cases had abscess size documented.
e
The number of surgical procedures performed refers only to those performed during the index admission.
f
Delayed source control was defined as >3 calendar days from the time of admission until first surgical source control.
g
PVL, Panton-Valentine leucocidin.
h
agr refers to accessory gene regulator group.