TABLE 3.
Univariable associations of chronic osteomyelitis and microbiologic and molecular characteristics of MSSA
| Characteristic of MSSA | No. (%) of patients with: |
P value | |
|---|---|---|---|
| Progression to chronic osteomyelitis (n = 13) | No progression to chronic osteomyelitis (n = 237) | ||
| Clindamycin resistant | 3 (23.1) | 26 (10.9) | 0.18 |
| CzIEa | 5 (38.5) | 31 (13.1) | 0.02 |
| ≥ 4-fold increase in cefazolin MIC with high inoculum | 6 (46.2) | 84 (35.4) | 0.55 |
| Vancomycin Etest MIC of >1 μg/mlb | 3 (23.1) | 109 (45.9) | 0.15 |
| PVL positive | 5 (38.5) | 47 (19.8) | 0.15 |
| agrI | 6 (46.1) | 147 (62) | 0.26 |
| agrII | 2 (15.4) | 31 (13.1) | 0.67 |
| agrIII | 4 (30.7) | 36 (15.2) | 0.1 |
| agrIV | 0 | 9 (3.8) | 1 |
| agr nontypeable | 1 (7.6) | 14 (5.9) | 0.56 |
a
CzIE was defined as a high-inoculum cefazolin MIC of ≥16 μg/ml.
b
No isolate had a vancomycin Etest MIC of >2 μg/ml.