TABLE 2.

Final parameter estimates for the two-compartment caspofungin population pharmacokinetic model

Pharmacokinetic parametera	Mean	SD	Median	CV%
Ke (h−1)	0.09	0.04	0.08	42.38
V0 (liters/kg)	7.71	2.70	7.20	34.98
kcp (h−1)	0.44	0.38	0.28	88.02
kpc (h−1)	0.46	0.35	0.34	75.98

^aK_e, elimination rate constant; V₀, volume of distribution; k_cp, rate constant for the caspofungin distribution from the central to the peripheral compartment; k_pc, rate constant for the caspofungin distribution from the peripheral to the central compartment.