TABLE 5.

Probability of target attainment for AUC/MIC targets of 450, 865, and 1,185 for 3rd day of caspofungin therapy (48 to 72 h)

Dose (mg/kg) and species	PTA (%) for MIC (mg/liter) ofa:
	0.01	0.03	0.06	0.1	0.25	0.5	1.0
2–1 mg/kg
C. glabrata	100	100	100	100	62	2	0
C. albicans	100	100	100	99	3	0	0
C. parapsilosis	100	100	100	49	0	0	0
1.5–1.25 mg/kg
C. glabrata	100	100	100	100	95	7	0
C. albicans	100	100	100	100	9	0	0
C. parapsilosis	100	100	100	87	0	0	0
2–1.25 mg/kg
C. glabrata	100	100	100	100	97	9	0
C. albicans	100	100	100	100	11	0	0
C. parapsilosis	100	100	100	92	0	0	0
1 mg/kg
C. glabrata	100	100	100	100	44	0	0
C. albicans	100	100	100	97	1	0	0
C. parapsilosis	100	100	98	35	0	0	0
1.5 mg/kg
C. glabrata	100	100	100	100	99	16	0
C. albicans	100	100	100	100	19	0	0
C. parapsilosis	100	100	100	99	2	0	0
70 mg
C. glabrata	100	100	100	100	29	0	0
C. albicans	100	100	100	75	0	0	0
C. parapsilosis	100	100	98	26	0	0	0
70–50 mg
C. glabrata	100	100	100	99	8	0	0
C. albicans	100	100	98	26	0	0	0
C. parapsilosis	100	100	48	6	0	0	0
100 mg
C. glabrata	100	100	100	100	93	6	0
C. albicans	100	100	100	99	9	0	0
C. parapsilosis	100	100	100	84	0	0	0
100–70 mg
C. glabrata	100	100	100	100	31	0	0
C. albicans	100	100	100	82	0	0	0
C. parapsilosis	100	100	98	28	0	0	0

^aAn AUC/MIC target of 450 was used for Candida glabrata, 865 for Candida albicans, and 1,185 for Candida parapsilosis.