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Probability of target attainment (100% fT>4×MIC) for cefepime regimens in critically ill adult patients after the first dose (A), after the first 24 h (B), and after 72 h of regular dosing (C). Horizontal dashed lines indicate a 90% probability of target attainment. The mean (SD) creatinine clearance and weight used for the simulations were 116 (92) ml/min and 86 (34) kg, respectively. CI, continuous infusion; EI, extended infusion; II, intermittent infusion.
