TABLE 3.
Guidance on initial cefepime dosing regimens to achieve 100% fT>MIC in critically ill adult patients based on different renal functions and MICs
| MIC (mg/liter) | Cefepime dosing regimena at the following creatinine clearance (ml/min): |
||||
|---|---|---|---|---|---|
| 10–30 | >30–60 | >60–90 | >90–120 | >120–150 | |
| 1 | 2 g q12h (II) | 2 g q12h (II) | 2 g q8h (II) | 2 g q8h (II) | 2 g q8h (EI) |
| 2 | 2 g q12h (II) | 2 g q8h (II) | 2 g q8h (II) | 2 g q8h (EI) | 6-g CI |
| 4 | 2 g q12h (II) | 2 g q8h (II) | 2 g q8h (EI) | 7- to 8-g CI | 8-g CI |
| 8 | 2 g q8h (II) | 2 g q8h (EI) | 2 g q6h (EI) | 4-g LD, 6-g CI | 4-g LD, 7-g CI |
| 16 | 2 g q6h (II) | 4-g LD, 6-g CI | 4-g LD, 6-g CIb | 4-g LD, 8-g CIb | 4-g LD, 8-g CIb |
a
CI, continuous infusion; EI, extended infusion over half the dosing interval; II, intermittent infusion over 30 min; LD, loading dose over 4 h.
b
Target attainment between 80% and 90%.